详情描述
MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.
Product information
CAS Number: 1005264-47-0
Molecular Weight: 474.57
Formula: C27H26N2O4S
Chemical Name: 4-{8-[(3, 4-dimethylphenyl)sulfamoyl]-3H, 3aH, 4H, 5H, 9bH-cyclopenta[c]quinolin-4-yl}benzoic acid
Smiles: CC1=CC=C(C=C1C)NS(=O)(=O)C1=CC2C3C=CCC3C(NC=2C=C1)C1C=CC(=CC=1)C(O)=O
InChiKey: XCBONKHCCRJMNW-UHFFFAOYSA-N
InChi: InChI=1S/C27H26N2O4S/c1-16-6-11-20(14-17(16)2)29-34(32,33)21-12-13-25-24(15-21)22-4-3-5-23(22)26(28-25)18-7-9-19(10-8-18)27(30)31/h3-4,6-15,22-23,26,28-29H,5H2,1-2H3,(H,30,31)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (210.72 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro.
In Vivo:
MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo.
References:
- Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636
Products are for research use only. Not for human use.