LEESGGGLVQPGGSMK TFA

LEESGGGLVQPGGSMK TFA, a proteolysis peptide, is a component of Infliximab. LEESGGGLVQPGGSMK TFA can be used for quantitative analysis of Infliximab. Infliximab is a chimeric monoclonal IgG1 antibody that specifically binds to TNF-α.

Product information

Molecular Weight: 1659.74

Formula: C66H109F3N18O26S

Chemical Name: (4S, 7S, 10S, 22S, 25S, 28S)-1-amino-4-((S)-2-((7S, 10S, 17S)-17-amino-17-carboxy-7-(hydroxymethyl)-10-(2-(methylthio)ethyl)-2, 5, 8, 11-tetraoxo-3, 6, 9, 12-tetraazaheptadecylcarbamoyl)pyrrolidine-1-carbonyl)-28-((S)-2-amino-4-methylpentanamido)-25-(2-carboxyethyl)-22-(hydroxymethyl)-10-isobutyl-7-isopropyl-1, 6, 9, 12, 15, 18, 21, 24, 27-nonaoxo-5, 8, 11, 14, 17, 20, 23, 26-octaazahentriacontan-31-oic acid compound with 2, 2, 2-trifluoroacetic acid (1:1)

Smiles: CSCC[C@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(=O)NCCCC[C@H](N)C(O)=O.OC(=O)C(F)(F)F

InChiKey: BFUOGNQKXQNITD-AJFXFXTASA-N

InChi: InChI=1S/C64H108N18O24S.C2HF3O2/c1-32(2)23-36(66)54(95)76-37(14-17-51(91)92)57(98)77-38(15-18-52(93)94)58(99)80-42(30-83)56(97)72-26-47(87)69-25-46(86)70-28-49(89)74-41(24-33(3)4)59(100)81-53(34(5)6)62(103)79-40(13-16-45(67)85)63(104)82-21-10-12-44(82)61(102)73-27-48(88)71-29-50(90)75-43(31-84)60(101)78-39(19-22-107-7)55(96)68-20-9-8-11-35(65)64(105)106;3-2(4,5)1(6)7/h32-44,53,83-84H,8-31,65-66H2,1-7H3,(H2,67,85)(H,68,96)(H,69,87)(H,70,86)(H,71,88)(H,72,97)(H,73,102)(H,74,89)(H,75,90)(H,76,95)(H,77,98)(H,78,101)(H,79,103)(H,80,99)(H,81,100)(H,91,92)(H,93,94)(H,105,106);(H,6,7)/t35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,53-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The anti-TNF antibodies blocking the action of TNF alpha revolutionized therapy of TNF-related diseases such as Inflammatory Bowel Disease, lupus, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis. By neutralizing TNF activity, anti-TNF antibodies promote mucosal healing and induce long-term remissions in vivo. The main anti-TNF antibodies that are currently authorized encompass Infliximab, Etanercept, Adalimumab, Certolizumab and Golimumab.

References:

1. Dorothée LEBERT, et al. A method for quantifying therapeutic antibodies. EP3371592A1.

Products are for research use only. Not for human use.