6-Dehydrogingerdione

6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5.

Product information

CAS Number: 76060-35-0

Molecular Weight: 290.35

Formula: C17H22O4

Chemical Name: (1E)-1-(4-hydroxy-3-methoxyphenyl)dec-1-ene-3, 5-dione

Smiles: CCCCCC(=O)CC(=O)/C=C/C1=CC(OC)=C(O)C=C1

InChiKey: JUKHKHMSQCQHEN-VQHVLOKHSA-N

InChi: InChI=1S/C17H22O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h7-11,20H,3-6,12H2,1-2H3/b9-7+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

6-Dehydrogingerdione could trigger apoptotic cell death via both mitochondrial- and Fas receptor-mediated pathways. 6-Dehydrogingerdione (6-DG) up-regulates Ser-15 phosphorylation and evoked p53 nuclear translocation. 6-Dehydrogingerdione (6-DG) induces mitochondrial apoptotic pathway.

References:

1. Chung-Yi Chen, et al. 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. J Agric Food Chem. 2010 May 12;58(9):5604-11.

Products are for research use only. Not for human use.