AdipoRon, Adiponectin Receptor/AdipoR agonist

AdipoRon is a novel, highly potent, selective and orally active small molecule agonist of adiponectin receptor (AdipoR). AdipoRon binds to both AdipoR1 and AdipoR2 (EC50 for AdipoR1 ~1.8 µM and AdipoR2 ~3.1 µM). AdipoRon showed very similar effects to adiponectin in muscle and liver, such as activation of AMPK and PPAR-α pathways, and ameliorated insulin resistance and glucose intolerance in mice fed with a high-fat diet, which was completely obliterated in AdipoR1 and AdipoR2 double-knockout mice. Moreover, AdipoRon ameliorated diabetes of genetically obese rodent model db/db mice, and prolonged the shortened lifespan of db/db mice on a high-fat diet. AdipoRon could serve as a very useful chemical probe for studies of obesity-related diseases such as type 2 diabetes by activating AdipoR1 and AdipoR2.

Product information

CAS Number: 924416-43-3

Molecular Weight: 428.52

Formula: C27H28N2O3

Chemical Name: 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide

Smiles: O=C(COC1C=CC(=CC=1)C(=O)C1C=CC=CC=1)NC1CCN(CC2C=CC=CC=2)CC1

InChiKey: SHHUPGSHGSNPDB-UHFFFAOYSA-N

InChi: InChI=1S/C27H28N2O3/c30-26(28-24-15-17-29(18-16-24)19-21-7-3-1-4-8-21)20-32-25-13-11-23(12-14-25)27(31)22-9-5-2-6-10-22/h1-14,24H,15-20H2,(H,28,30)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO, not in water

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

AdipoRon was used at 10-25 µM final concentration in vitro and in cellular assays.

In Vivo:

AdipoRon was administered orally to mice at 50 mg/kg once per day.

References:

1. Okada-Iwabu, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. (2013) Nature. 503(7477):493-9.

Products are for research use only. Not for human use.