CAY10603, HDAC6 Inhibitor

CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM. It has 271 nM, 252 nM, 0.42 nM, 6851 nM, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. CAY10603 has potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 μM. It could be useful chemical probe to study HDAC biology.

Product information

CAS Number: 1045792-66-2

Molecular Weight: 446.50

Formula: C22H30N4O6

Chemical Name: tert-butyl (4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenyl)carbamate

Smiles: CC(C)(C)OC(=O)NC1C=CC(=CC=1)C1=CC(=NO1)C(=O)NCCCCCCC(=O)NO

InChiKey: WWGBHDIHIVGYLZ-UHFFFAOYSA-N

InChi: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)

Technical Data

Appearance: Solid Power.

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO up to 100 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined.

HS Tariff Code: 382200

How to use

In Vitro:

CAY10603 was used at 0.1-1 µM final concentration in various in vitro assays.

References:

1. Kozikowski AP, et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. (2008) J Med Chem. 51(15):4370-3.

Products are for research use only. Not for human use.