详情描述
Alsterpaullone (Alp, 9-Nitropaullone, NSC 705701) is a potent inhibitor of CDK with IC50 of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also acts as a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 of both 4 nM for GSK-3α and GSK-3β. Alsterpaullone induces apoptosis by activation of caspase-9. Alsterpaullone has antitumor activity and possesses potential for the treatment of neurodegenerative and proliferative disorders.
Product information
CAS Number: 237430-03-4
Molecular Weight: 293.28
Formula: C16H11N3O3
Chemical Name: 7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one
Smiles: [O-][N+](=O)C1=CC=C2NC3=C(CC(=O)NC4=CC=CC=C43)C2=C1
InChiKey: OLUKILHGKRVDCT-UHFFFAOYSA-N
InChi: InChI=1S/C16H11N3O3/c20-15-8-12-11-7-9(19(21)22)5-6-14(11)18-16(12)10-3-1-2-4-13(10)17-15/h1-7,18H,8H2,(H,17,20)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Tyler Lahusen, et al. Mol Carcinog. 2003 Apr;36(4):183-94.
- M Leost, et al. Eur J Biochem. 2000 Oct;267(19):5983-94.
Products are for research use only. Not for human use.