TBK1/IKKε-IN-2

TBK1/IKKε-IN-2 (Ikk epsilon-in-1, IKKε-IN-1, MDK10496) is a dual inhibitor of TBK1 and IKKε.

Product information

CAS Number: 1292310-49-6

Molecular Weight: 457.52

Formula: C26H27N5O3

Synonym:

Ikk epsilon-in-1

IKKε-IN-1

MDK10496

Chemical Name: 5-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile

Smiles: N#CC1=CC(=CC=C1OC1CCOCC1)C1=CC=NC(NC2C=CC(=CC=2)N2CCOCC2)=N1

InChiKey: BWABTWGSXHTHCG-UHFFFAOYSA-N

InChi: InChI=1S/C26H27N5O3/c27-18-20-17-19(1-6-25(20)34-23-8-13-32-14-9-23)24-7-10-28-26(30-24)29-21-2-4-22(5-3-21)31-11-15-33-16-12-31/h1-7,10,17,23H,8-9,11-16H2,(H,28,29,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 60 mg/mL (131.14 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Asli Muvaffak, et al. Mol Cancer Res. 2014 Jul;12(7):1055-66.

Products are for research use only. Not for human use.