NP-G2-044 --- fascin inhibitor

NP-G2-044 is a potent, orally active inhibitor of the actin-bundling activity of fascin with IC50 of ~0.2 μM. NP-G2-044 blocks tumor metastasis and increases antitumor immune response.

Product information

CAS Number: 1807454-59-6

Molecular Weight: 399.37

Formula: C21H16F3N3O2

Chemical Name: 2-Methyl-N-(1-((4-(trifluoromethyl)phenyl)methyl)-1H-indazol-3-yl)-3-furancarboxamide

Smiles: CC1OC=CC=1C(=O)NC1=NN(CC2C=CC(=CC=2)C(F)(F)F)C2=CC=CC=C21

InChiKey: XLLRLAABUFOJPC-UHFFFAOYSA-N

InChi: InChI=1S/C21H16F3N3O2/c1-13-16(10-11-29-13)20(28)25-19-17-4-2-3-5-18(17)27(26-19)12-14-6-8-15(9-7-14)21(22,23)24/h2-11H,12H2,1H3,(H,25,26,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO 100 mg/mL (143.93 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Annette Säfholm, et al. Clin Cancer Res. 2008 Oct 15;14(20):

Products are for research use only. Not for human use.