BAY 707

Potent and selective MTH1 inhibitor (IC50 = 2.3 nM). Exhibits no significant activity at 1 μM concentration against a panel of 97 kinases. Cell-permeable and active in vivo. Displays no antitumor activity in vitro or in vivo.

Product information

CAS Number: 2109805-96-9

Molecular Weight: 288.34

Formula: C15H20N4O2

Synonym:

BAY-707

BAY707

BAY-707 free base

Related CAS Number:

2223023-19-4 (BAY-707 acetate)

Chemical Name: N-Ethyl-4-[(3S)-3-methylmorpholin-4-yl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide

Smiles: CCNC(=O)C1=CC2=C(N1)N=CC=C2N1CCOC[C@@H]1C

InChiKey: RPMGXDCRCWWCRY-JTQLQIEISA-N

InChi: InChI=1S/C15H20N4O2/c1-3-16-15(20)12-8-11-13(4-5-17-14(11)18-12)19-6-7-21-9-10(19)2/h4-5,8,10H,3,6-7,9H2,1-2H3,(H,16,20)(H,17,18)/t10-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Ellermann M, et al. Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.ACS Chem Biol. 2017 Aug 18;12(8):1986-1992.

Products are for research use only. Not for human use.