详情描述
Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively.
Product information
CAS Number: 1488354-15-9
Molecular Weight: 487.38
Formula: C23H16F3N3O6
Synonym:
BAY1142524
BAY-1142524
BAY 1142524
Chemical Name: 1-(3-methyl-2-oxo-2, 3-dihydro-1, 3-benzoxazol-6-yl)- 2, 4-dioxo-3-[(1R)-4-(trifluoromethyl)-2, 3-dihydro-1H-inden- 1-yl]-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylic acid
Smiles: CN1C2=CC=C(C=C2OC1=O)N1C=C(C(O)=O)C(=O)N([C@@H]2CCC3C(=CC=CC=32)C(F)(F)F)C1=O
InChiKey: JDARDSVOVYVQST-MRXNPFEDSA-N
InChi: InChI=1S/C23H16F3N3O6/c1-27-17-7-5-11(9-18(17)35-22(27)34)28-10-14(20(31)32)19(30)29(21(28)33)16-8-6-12-13(16)3-2-4-15(12)23(24,25)26/h2-5,7,9-10,16H,6,8H2,1H3,(H,31,32)/t16-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 97 mg/mL(199.02 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Friederike Kanefendt, et al. Clin Pharmacol Drug Dev. 2019 May;8(4):467-479.
- Hanna Tinel, et al. Circulation. November 14, 2017.Vol 136, Issue suppl_1.
Products are for research use only. Not for human use.