Amikacin disulfate

Amikacin is an antibiotic used for a number of bacterial infections. This includes joint infections, intraabdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. It is also used for the treatment of multidrug-resistant tuberculosis. It is used either by injection into a vein or muscle. Amikacin is in the aminoglycoside family of medications. It works by blocking the function of the bacteria's 30S ribosomal subunit, making it unable to make protein.

Product information

CAS Number: 39831-55-5

Molecular Weight: 781.76

Formula: C22H47N5O21S2

Synonym:

Pierami

Amikacin bis(sulphate)

Amikin sulfate

BAY-416651 sulfate

Chemical Name: (S)-4-amino-N-((1R, 2S, 3S, 4R, 5S)-5-amino-2-((2S, 3R, 4S, 5S, 6R)-4-amino-3, 5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-4-((2R, 3R, 4S, 5S, 6R)-6-(aminomethyl)-3, 4, 5-trihydroxytetrahydro-2H-pyran-2-yloxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide bis(sulfate)

Smiles: N[C@H]1C[C@@H](NC(=O)[C@@H](O)CCN)[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](N)[C@H]2O)[C@@H](O)[C@@H]1O[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O.OS(O)(=O)=O.OS(O)(=O)=O

InChiKey: FXKSEJFHKVNEFI-GCZBSULCSA-N

InChi: InChI=1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Water: 10 mM

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Umezawa H. Jpn J Antibiot, 1979, 32 Suppl, S1-S14.
2. Gangadharam PR, et al. Antimicrob Agents Chemother, 1988, 32(9), 1400-1403.
3. Xiong YQ, et al. Antimicrob Agents Chemother, 1997, 41(4), 823-826.

Products are for research use only. Not for human use.